Best Over/Under Bets of NFL Week 6: Chasing Good Offense and Bad Defense

In Week 5, taking the Under was slightly more profitable than taking it over. Here are the top NFL Week 6 Over/Under bets.

The New England Patriots-Detroit Lions game didn't eclipse the 47-point projected total.

Panthers-Rams is under 41 (-110 via DraftKings) Cardinals-Seahawks are over 50.5 (- 110 via draftkds) Bills-Chiefs is over 54 (-100 via Caesars).

Panthers-Rams, Cardinals-Seahawks, Seahawks-Cardinals, Bills-Chiefs and Bills/Chief's game are the best bets of NFL Week 6.

Matt Rhule was fired as head coach of Carolina and the team will start a third-string quarterback. Los Angeles is the NFL's fourth worst team and has averaged just 16 points per game this season.

The Over/Under for this game has risen to 50.5. The game is expected to be a shootout. Both teams have injuries to their running backs. Seattle's Rashaad Penny is out for the season, while Arizona's James Conner and Darrel Williams are injured.

The Chiefs and Bills are the AFC's top two teams. Buffalo is tied for first in the league in opponent PPG with 12.2. The Chiefs are also the highest scoring team this season (31.8 POG). The Over is high, but the Chiefs should be able to cash.

Best Over/Under bets of NFL Week 6 are Chasing Good Offense and Bad Defense. NFL Season 6 Over-Under picks are made on 10/12/2022 at 2:12 p.m. ET.