Clemson vs. Notre Dame odds, prediction, betting trends for Week 10 matchup

No. 5 Clemson Tigers (8-0) will play the Notre Dame Fighting Irish (5-3) at Notre Notre Stadium on Saturday at 7:30 p.m. ET. The Tigers are the frontrunners to win the ACC Atlantic division and are a contender for the College Football Playoff. Notre Fighting Ireland are looking to become bowl eligible with a win. Clemson and Notre Irish have a 4-2 all-time series record. The last time these two teams played each other was in theACC title game in '20.

Clemson is favored by 4.5 points. Notre Dame is +162.

Clemson is 6-0 straight up in their past six games against FBS Independent teams. The Tigers are 20-5 after a bye week under Dabo Swinney. Notre Dame is 17-3 straight-up in its last 20 home games and 6 -0 against the spread in the last six ACC games.

Uiagalelei was benched two weeks ago because he threw two interceptions. Before that, he had only two interception in the first seven games. Notre Dame is averaging 186.6 rushing yards per game this season and has run for 230 yards in back-to-back games, but Clemson is allowing just 87.9 rushingyards per games and is expected to give up a lot of yards to Will Shipley. Shiply has been one of the better running backs in college football this year, rushing for 739 yards and 10 touchdowns.

Clemson is playing for a conference title and CFP berth. Notre Dame has been playing well since their 1-2 start earlier this season. Drew Pyne has played well this year as a starter for the Fighting Irish. Clemson has the advantage at quarterback with veteran Uiagalelei.

Clemson covers the spread and keeps their undefeated season alive.