Clemson vs Wake Forest Odds, Spread and Picks

The first game of the week takes place between #5 Clemson and #21 Wake Forest. Both teams are off to perfect starts. The Demon Deacons survived a scare from Liberty last week. Clemson has won each of its three games by at least 23 points.

Clemson is favored by 7 points in the game against Wake Forest. The game is scheduled for noon ET at Truist Field in Winston-Salem, North Carolina. ABC will broadcast the match.

Clemson beat Louisiana Tech 48-20 last Saturday. DJ Uiagalelei threw two touchdowns for the second straight game. Will Shipley rushed for 139 yards and two scores in the third game of the season. Wake Forest's defense is ranked 70th in rush defense. Clemson is a top-four National Championship odds contender. The Tigers' defense has been strong, but they haven't faced a dynamic offense yet.

Wake Forest is 3-0 and their offense is very good. Their defense is suspect, but they have played well against Liberty, Vanderbilt and VMI. Clemson is a team that has a good chance to win.  Clemson vs Wake Forest Odds, Spread and Picks.

All three of Wake Forest's games have produced at least 54 points. The teams played to a 48-27 Clemson victory in 2021. Clemson is averaging 50 points per game versus the Demon Deacons in their last four meetings.