College Football Disaster Watch: Top Upset Picks, Predictions for Week 3

There was a history-making week on the college football upset front. Sun Belt teams have a golden opportunity to continue the conference's run of success in the underdog role.

Marshall, Appalachian State, Washington State and Georgia Southern upset the favorites last Saturday. The Sun Belt Conference and Washington University made college football betting history. This week's games are more unpredictable. The top college sports betting picks for Week 3 are below.

Marshall, Appalachian State, Washington State and Georgia Southern are picking ups for the College Football Championship Game in Week 3.

BetMGM gives 4 free bets of $50 each on college football teams to win outright. Free bets must be used within 7 days of being credited to your account.

Old Dominion was beaten by Virginia Tech in its Week 1 encounter. The Monarchs won 20-17 thanks to their defense forcing five turnovers. Old Dominion has 10 starters back on offense and seven on defense this season. Virginia's offense is unproven and the team lost to Illinois last week. Old Dominion lost 18-point to East Carolina last weekend.

Tulane is 2-0 after a disappointing season. The Green Wave are a two-touchdown underdog against Kansas State. Tulane won just two games last season, but they have nine starters back on both sides of the ball. Sophomore quarterback Michael Pratt has opened the season with two gaudy statistical performances. Last time Tulan almost upset Oklahoma as 32-point underdogs.

Fresno State is a +380 favorite against USC. The Bulldogs lost to Oregon State last week. USC has won the first two games of the season. There are concerns about the Trojans' defense. Fresno State has the most potent offensive attack that USC's faced so far this season and has eight returning starters.

The college football upset picks for Week 3 are made 9/15/2022 at 1:56 p.m. ET.