College football odds, lines, spreads: Picks, predictions, betting advice for Week 4, 2023 from proven model

The Week 4 college football schedule is loaded with ranked vs. ranked matchups, including No. 9 Notre Dame vs. No. 6 Ohio State. Notre Dame stayed unbeaten with its 41-17 win over Central Michigan last week, while Ohio State cruised to a 63-10 win against Western Kentucky. The Buckeyes are 3-point road favorites in the Week 4 college football odds from SportsLine consensus. Another enticing matchup on Saturday night features No. 7 Penn State (-14) vs. No. 24 Iowa in a Big Ten on CBS showdown. 

Before making any college football picks for those games or others in Week 4, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 4 game, and the results are in. 

One of the college picks the model is high on during Week 3: Baylor (+14.5) easily stays within the spread against No. 3 Texas in a 7:30 p.m. ET kickoff at McLane Stadium. Baylor is coming off its first win of the season, cruising to a 30-7 victory over LIU last week, while Texas failed to cover the 31-point spread in its 31-10 win over Wyoming. The Bears are covering the spread in well over 60% of the model's simulations. 

Another prediction: Arkansas (+18) plays a competitive road game at No. 12 LSU on Saturday at 7 p.m. ET. Arkansas blew a double-digit lead in a 38-31 loss to BYU last week, but the model does not expect that loss to bleed into this performance. The Razorbacks are covering this large spread 60% of the time, keeping the game closer than the betting market expects. 

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple other underdogs to win outright!