College Football Picks Against the Spread Week 1

Week 1 of the 2022 College Football season features several matchups with possible College football playoff implications. The game between No. 5 Notre Dame and No 2 Ohio State is the clear headliner. Oregon takes on the defending national champs in a virtual home game for the Bulldogs in Atlanta. Cincinnati travels to Arkansas.

College Football Picks Against the Spread Week 1 are all odds as of August 30th at Barstool Sportsbook.

Notre Dame is the underdog against Ohio State in 2022 CFP Semifinal. Marcus Freeman will be making his head coaching debut. OSU has a talented team with a lot of potential. The Buckeyes are motivated after falling short of expectations last season. Oregon stunned Ohio state last year at the Horseshoe. Alabama beat Notre Dame 31-14 in the 2021 CfP SemIFinal in that game.

Oregon is trying to knock off the reigning champs Georgia. Bo Nix is expected to start for Oregon. Georgia has advantages over Oregon in virtually every aspect. The front-seven on Georgia's defense should be one of the best in the country in 2022. Georgia quarterback Stetson Bennett is less comfortable when he is forced to pass.

Cincinnati is a favorite at +6 against Arkansas. The Bearcats are coming off their appearance in college football's final four. Arkansas is 19-3 in season-opening games since 2006.