Creighton vs. Butler odds, line: 2022 college basketball picks, Jan. 26 prediction from proven computer model

The Creighton Bluejays have an opportunity to get back near the top of the Big East standings over their next few games, but that starts with a pivotal matchup at Butler on Wednesday night. The Bluejays have won their last two games, but haven't won three in a row since the end of November. Bulldogs sophomore guard Chuck Harris had a breakout game against Providence in his last start, but his team has lost four straight, and is looking to stop the bleeding with an upset at home.

Game time from Hinkle Fieldhouse is set for 6:30 p.m. ET, where the Bulldogs are 2-7 against the spread this season. The Bluejays are favored by 2.5 points in the latest Butler vs. Creighton odds from Caesars Sportsbook, and the over-under is set at 126.5. Before entering any Creighton vs. Butler picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. It enters Week 12 of the season with a 49-36 record on all top-rated college basketball picks, returning almost $700. Over the past five-plus years, the proprietary computer model has generated an impressive profit of $2,800 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Butler vs. Creighton. You can head to SportsLine to see its picks. Here are several college basketball odds for Creighton vs. Butler:

• Butler vs. Creighton spread: Butler +2.5
• Butler vs. Creighton over-under: 126.5 points

What you need to know about Butler

Butler came up short against Providence on Sunday, 69-62, but a silver lining for Butler was the play of guard Bo Hodges, who had 17 points along with eight rebounds. The Bulldogs lost their previous two games -- both to No. 20 Connecticut -- by 19 points apiece, and by 40 points at Villanova on January 16. Hodges only averages 5.4 points and 5.4 rebounds per game, and Sunday's outing was his first double-digit scoring night of the season. Harris averages just over 10 points per start, but had 21 in the losing effort.

Butler hasn't put up big point totals this season, but the Bulldogs do a good job of limiting mistakes in possession. Butler's opponents average just under six steals per game and the Bulldogs turn it over just 12.6 times. However, Butler is one of the lowest-volume shooting teams in the nation, and average just under 53 attempts each contest.

What you need to know about Creighton

Creighton didn't have too much trouble with the DePaul Blue Demons at home this past Saturday and won 60-47. Creighton's center Ryan Kalkbrenner posted a double-double on 18 points and 10 rebounds in addition to six blocks. Trey Alexander was the team's second-leading scorer, and came away with 12 points off the bench.

The Bluejays' defense has been strong this season, and has held opponents to just 39.5 percent from the field, which is one of the lowest marks in all of college basketball. In two of Butler's last four games, the Bulldogs made just 30 percent of their shots, so an early Bluejays lead would appear difficult for the Bulldogs to overcome.

How to make Butler vs. Creighton picks

The model has simulated Creighton vs. Butler 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 70 percent of simulations. You can only see the pick at SportsLine.