Kansas vs. Duke odds, line, spread: 2022 college football picks, Week 4 predictions from proven model

Kansas Jayhawks are 7-point favorites against Duke Blue Devils in the 2022 college football game. The game is scheduled for noon on Saturday. SportsLine's advanced computer model simulates every FBS college game 10,000 times and has returned a profit of more than $3,300 for $100 players on its top-rated college college sports picks.

Kansas and Duke are playing each other in college football. Kansas is favored by 7 points. The game is set for Saturday at 7 p.m.

Kansas vs. Duke is a college football game. The line is Kansas -7, the over/under is 63.5 points.

Kansas has covered the spread in six consecutive games. They beat West Virginia and Houston as underdogs. Duke has been overvalued in the betting market. It has won only twice in its last nine games overall.

Duke is off to a 3-0 start. The Blue Devils beat Temple in the first game. They also have wins over Northwestern and North Carolina A&T. Riley Leonard has been efficient, completing 72.7% of his passes for 723 yards and five touchdowns. He has also racked up 147 yards on the ground.

The model simulates Duke vs. Kansas 10,000 times and it's picking Duke. SportsLine's model is leaning over.