LSU vs. Alabama prediction, odds, spread, line, start time: Proven expert releases CFB picks, best bets, props for SEC West matchup

The No. 14 LSU Tigers (6-2, 4-1 SEC) and the No. 6 Alabama Crimson Tide (7-1, 5-0 SEC) are set to square off in their annual meeting on Saturday at Bryant-Denny Stadium in Tuscaloosa. Kickoff on CBS and Paramount+ is at 7:45 p.m. ET. LSU enters this matchup on a three-game winning streak after beating Army 62-0 in its last outing. Alabama has won six straight, and beat Tennessee 34-20 on Oct. 21. Both teams are coming off bye weeks. LSU won last year's matchup 32-31 in overtime, but Alabama leads the all-time series 55–27–5.

The Crimson Tide are 3-point favorites in the latest Alabama vs. LSU odds via SportsLine consensus, while the over/under for total points scored is 61.5. Alabama is a -161 (risk $161 to win $100) favorite on the money line, with LSU listed as a +135 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any LSU vs. Alabama picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has been red-hot all season, going 40-17-2 on his college football best bets for SportsLine this season so far! Anyone who has followed his picks is WAY UP!

Kaylor knows that this is one of the fiercest rivalries in college football, and the Tide have one of the nation's best home field advantages at Bryant-Denny Stadium. Alabama has an elite defense, and quarterback Jalen Milroe is improving with every passing week. The Crimson Tide are 5-3 against the spread this season, and were dominant in the second half of their win over Tennessee. 

Kaylor, however, also factored in LSU's recent run of stellar offensive play. Quarterback Jayden Daniels has played himself into the Heisman Trophy conversation, completing 73.1% of his passes for 2,573 yards, 25 touchdowns, and three interceptions. The Tigers are 4-3 against the spread this season and defeated Alabama 32-31 in last year's matchup.

Now, Kaylor has locked in a confident against-the-spread pick for LSU vs. Alabama. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.