Michigan State vs. Washington odds, prediction: 2022 Week 3 college football picks by model on 50-41 run

The Michigan State Spartans and Washington Huskies are playing each other in a non-conference game on Saturday at 7:30 p.m. ET. The Spartans are coming off a 52-0 win over Akron last Saturday. Washington is 2-1 and the Husky's defeated Portland State 52.6. SportsLine's advanced computer simulation model simulates every FBS college football game 10,000 times and has returned a profit of almost $3,400 for $100 players on its top-rated collegeFootball picks.

SportsLine's computer model has made its picks and CFB predictions for Michigan State vs. Washington. The model is very confident in its predictions. Michigan is 4-0 against the spread in their last four games.

Michigan State vs. Washington is a college football game. The Spartans are 4-0 against the spread in their last four games. Seattle is 7-2 ATS in its last nine non-conference games and 56.5 points are on the over/under.

Michigan State is led by running back Jalen Berger, a Wisconsin transfer. He rushed for 120 yards and one touchdown in his debut against Western Michigan and three touchdowns against Akron. Graduate senior Jarek Broussard scored two rushing touchdowns for his first multi-rushing touchdown outing of his career.

Washington is led by a veteran quarterback in junior Michael Penix Jr. Penx played at Indiana from 2018 to 2021. Wayne Taulapapa is a graduate student and running back who played against Kent State. He played in 40 games at Virginia, including 27 starts.

SportsLine's model is leaning Under on the total, projecting 52 combined points. One side of the spread hits in almost 70% of simulations.