NFL Week 10 Odds, Picks, Predictions and Best Bets for Every Game

NFL Week 10 betting board is very tricky. Only five games have totals north of 45.5. Last week, underdogs went 7-4-2 and totals landed at 4-9 to the under. RotoWire has NFL picks articles each week of the NFL season. Michael Rathburn's NFL Week10 line movement article is a detailed breakdown of biggest lines and market shifts. In this article, we dig into the full NFL odds and give our picks against the spread and on the totals for all 14 games.

Panthers and Falcons are playing each other on a quick turnaround. The Falcons have a slight advantage at the moment.

Buccaneers covered the spread at home last week. Seattle has gone over in four of five road games. Buccaneers are favored by 2.5 points.

Bills vs. Vikings is a game that is heavily influenced by Josh Allen's elbow injury. The spread has been reduced from -9.5 to -5.

Bears are favored by -2.5 at home against the Lions. The total is under 48. Bears' defense is shaky, but I think this game goes under.

The Chiefs are favored by 9.5 points against the Jaguars. The Jaguars just won a thrilling game over the Raiders. It's the first time the Chiefs have covered at home this season.

The Dolphins are favored by 3.5 points against the Browns. Miami has not been good against spreads in the past. The Dolphins won't be able to dominate the line of scrimmage like they did against Cincinnati.

Giants are coming off the bye and have been great against the spread at home (3-1). Houston comes off a mini-bye and has been a respectable 2-2-0 ATS on the road. The Texans are favored by 6.5 points.

The Saints are struggling and they travel to Pittsburgh to play the Steelers. New Orleans is 0-3 ATS on the road and with little promise of reinforcements coming on offense. Pittsburgh is coming off a bye.

Titans are favored to beat Denver. Denver has been brutal all year. Tennessee just gave Kansas City a tough game.

Raiders are playing against the Colts. Indianapolis is taking its clown show on the road with Jeff Saturday at the helm and possibly Dan Orlovsky having some say. Vegas is trying and failing in new and inventive ways.

Green Bay is struggling and losing. Dallas is going to be very public. DraftKings is picking Dallas to win by 5 points. Draft Kings is also picking the under 43.0 points to come for the game.

Rams are playing against the Cardinals. The Cardinals are not very good. The spread is Cardinals +3 (DraftKings) and the total is over 43.5 (PointsBet).

The 49ers are fresh off a bye and the Chargers just beat the Falcons. The Chargers are banged up but they still have Justin Herbert.

Eagles vs. Commanders is a game that is not popular with the public. DraftKings is picking the Commander's to cover the spread.

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Bucs-Seahawks is under 44.5 and Indianapolis-Las Vegas is over 42.

WynnBet offers a great offer for new players. The odds for NFL Week 10 are competitive.

DraftKings offers its best bets for NFL Week 10. Giants-Texans is under 41.0 and Titans-Titans is over 3.

FanDuel offers NFL Week 10 Odds, Picks, Predictions and Best Bets for every game.

BetRivers offers up to $500 in second-chance bets for NFL Week 10. Cardinals ML +145, Bears -2.5.

Steelers +2.5, Cardinals +43.0, Rams -43,5.