NFL Week 10 Predictions, Schedule, Odds, Spread & Total for Each Game

With Week 9 in the books, the 2023 NFL season has officially hit its second half. As the playoff picture continues to take shape, the Week 10 schedule is loaded with big-time matchups and wagering opportunities that casual and die-hard football bettors won’t want to miss.

Even though it’s still early in the week, it isn’t too early to start wondering where the best bets lie. Finding a starting point can be overwhelming, but that’s why your friends at Betting News are here.

This article addresses everything you need to know for the coming days, from the complete 14-game schedule and latest odds to my NFL Week 10 predictions and picks.

All NFL Week 10 odds are at 12:15 a.m. ET on Tuesday, Nov. 7.

Bye Week Teams: Chiefs, Rams, Dolphins, Eagles

NFL Week 10 Predictions & Odds: Thursday Night Football

Panthers vs Bears Odds

The Panthers’ flirtation with success wasn’t long-lived, falling 27-13 to the Indianapolis Colts last week. The Bears, meanwhile, suffered a second consecutive loss in the form of a 24-17 defeat to the New Orleans Saints.

While I’m not a fan of either time, I can’t trust the Bears as long as Tyson Bagent is under center. The 23-year-old has struggled over the last two games, tallying only two touchdown passes to five interceptions while being sacked 18 times.

Regardless of who wins this battle of basement-dwellers, don’t expect a ton of points. Not only is the Under 5-3 for Carolina this season, but Chicago’s last four games only saw an average of 39.5 points scored.

Panthers vs Bears Prediction: CAR wins

Panthers vs Bears Best Bet: u40 Total Points (-112)

NFL Week 10 Predictions & Odds: Sunday Morning

Colts vs Patriots Odds

The Colts managed to finally stop the bleeding in Week 9, walking out of Bank of America Stadium with a 27-13 win over the Carolina Panthers. Unfortunately, the same can’t be said for the Patriots, who fell 20-17 to the Washington Commanders.

The Patriots have been bad this season, so I don’t exactly trust them in international territory. The Colts’ offense has operated well with Gardner Minshew, so I don’t see them struggling to take advantage of a New England defense that surrenders seventh-most points and sixth-most total yards per game.

I also see Indianapolis covering the spread here. The Colts are 5-3 ATS in their last eight games, whereas the Patriots are a putrid 2-11 ATS in their previous 13 dating back to the 2022 campaign.

Colts vs Patriots Prediction: IND wins

Colts vs Patriots Best Bet: IND -2 (-107)

Texans vs Bengals Odds

The Texans are riding high after C.J. Stroud’s 470-yard, five-touchdown performance paved the way to a 39-37 win over the Tampa Bay Buccaneers. On the flip side, the Bengals extended their winning streak to four with a 24-18 win against the Buffalo Bills on Sunday Night Football.

While the Texans should celebrate their latest win, it doesn’t change the fact that they still surrendered 37 points while only stopping the Bucs on one of five red-zone trips. Are you trying to tell me that the Bengals’ offense isn’t licking their chops at this matchup?

While the Bengals will win, don’t expect the 46.5-point total to be surpassed. Despite the plethora of offensive talent involved, the Under is a combined 10-6 between these teams this season. On top of that, the last six Texans-Bengals matchups produced an average of 30.8 points.

Texans vs Bengals Prediction: CIN wins

Texans vs Bengals Best Bet: u46.5 Total Points (-110)

Saints vs Vikings Odds

The Saints enter the NFL Week 10 schedule after a 24-17 win over the Bears, their second of back-to-back victories. Meanwhile, the Vikings are riding a four-game winning streak following Sunday’s 31-28 win against the Atlanta Falcons led by Joshua Dobbs’ memorable performance.

The road team might be the favorites, but I’m siding with the Vikings. Minnesota’s offense looked better with Dobbs at the helm than it did with Kirk Cousins. Scoring won’t come as easily this time around, but it’s worth noting that the Saints have given up 27-plus points in two of their last three games.

Considering how New Orleans also owns a 2-5 ATS record in its seven previous games, Minnesota covering the spread is clearly this game’s best bet.

Saints vs Vikings Prediction: MIN wins

Saints vs Vikings Best Bet: MIN +2.5 (-107)

Packers vs Steelers Odds

The Packers earned a brief reprieve from their losing ways with last week’s 20-3 victory over the LA Rams. At the same time, the Steelers make for interesting foes after improving to 3-1 in their last four games with a 20-16 win against the Tennessee Titans on TNF.

Although both sides are coming off wins, I can’t say I feel confident about Green Bay. The Packers’ defense played well last week, but a lot of that had to do with facing Rams backup QB Brett Rypien. Kenny Pickett isn’t perfect, but he’s still better than a perennial journeyman.

Regardless of who wins, I’ll be sticking with the Under as the top betting pick. After all, each of the Packers’ last four games failed to surpass 37.5 points while four of the Steelers’ previous five did the same.

Packers vs Steelers Prediction: PIT wins

Packers vs Steelers Best Bet: u37.5 Total Points (-110)

Titans vs Buccaneers Odds

Both teams in this matchup could use a win in Week 10. The Titans dropped to 1-3 in their last four with a 20-16 loss to the Steelers while the Buccaneers’ 39-37 loss to the Texans marked their fourth consecutive defeat.

In what’s projected to be a pick ‘em situation, I’m rolling with the Buccaneers to turn things around. Their offense was productive last week, making it tough for the Titans to keep up if things are similar this time around. Furthermore, Tennessee is 0-4 with a minus-8.8 average scoring margin this season.

Back the Buccaneers to stop the bleeding in front of a rowdy home crowd.

Titans vs Buccaneers Prediction: TB wins

Titans vs Buccaneers Best Bet: TB PK (-110)

49ers vs Jaguars Odds

After starting the campaign 5-0, the 49ers fell to 0-3 in their last three games with a 31-17 loss to the Bengals. Meanwhile, the Jaguars haven’t lost since Week 3, winning their fifth straight game with a 20-10 effort against the Steelers on Oct. 29.

The 49ers have struggled to win lately, but they’re due for a bounce-back win. Both sides are coming off a bye week, so I can see a desperate San Francisco team getting on the board early. Jacksonville is only 1-2 at EverBank Stadium this season, so it isn’t like playing at home gives the Jags much of a boost.

Given that the Jaguars are 0-5 ATS in their last five games against the NFC West and 0-5 ATS in their last five games against the 49ers, San Francisco shouldn’t struggle to cover the spread on Sunday.

49ers vs Jaguars Prediction: SF wins

49ers vs Jaguars Best Bet: SF -3 (-110)

Browns vs Ravens Odds

The NFL Week 10 schedule also features this massive NFC North clash. The Browns’ vibes are high after a 27-0 shutout win over the Arizona Cardinals while the Ravens defeated the Seattle Seahawks 37-3 on Sunday, extending their winning ways to four games in a row.

While the Browns have played well, I can’t bring myself to go against the Ravens, who’ve dominated both sides of the ball during its winning streak. Given how unpredictable Cleveland’s offense can be, it could be a long night for the unit against a Baltimore defense that’s allowing 12.3 PPG over the last four outings.

With only 31 total points on the board when these divisional rivals previously met in Week 4, I’m comfortable with backing the Under again this weekend.

Browns vs Ravens Prediction: BAL wins

Browns vs Ravens Best Bet: u38 Total Points (-110)

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Now, back to the rest of the NFL Week 10 predictions…

NFL Week 10 Predictions & Odds: Sunday Afternoon

Falcons vs Cardinals Odds

The Falcons continued to struggle to reach the .500 mark, falling 31-28 to the Vikings in Week 9. Meanwhile, the Cardinals got absolutely nothing done against the Browns in their latest outing, suffering a 27-0 shutout loss.

Don’t even entertain the idea of the Cardinals winning. Even if they get Kyler Murray back from injury, it won’t erase the fact that Arizona has been held to 10 or fewer points in three of the last four games.

At the end of the day, the Falcons have experienced multiple wins this season, so take Arthur Smith’s squad to prevail.

Falcons vs Cardinals Prediction: ATL wins

Falcons vs Cardinals Best Bet: ATL PK (-118)

Lions vs Chargers Odds

All eyes are on the Lions to see if they can build off their first-half success as they return from their bye week. On the other side, the Chargers are searching for their third win in a row after hammering the New York Jets 27-6 on MNF.

The Chargers may have defeated the Bears, but the Lionse pose a more difficult test. Detroit has one of the NFL’s best offenses and we already saw how Los Angeles handles facing elite attacks, being outscored 51-34 in back-to-back losses to the Chiefs and Cowboys in Weeks 6 and 7.

Furthermore, the Lions being 3-1 ATS on the road has me confident that they can cover as the visitors.

Lions vs Chargers Prediction: DET wins

Lions vs Chargers Best Bet: DET -1.5 (-110)

Giants vs Cowboys Odds

This meeting marks the first Giants-Cowboys collision since Dallas’ 40-0 season-opening victory. Things don’t look all that promising for New York this time around after learning that QB Daniel Jones suffered a season-ending ACL tear in Week 9.

This is another matchup that I wouldn’t think too hard on. The Giants are among the NFL’s worst times while the Cowboys at least look like contenders when they’re on their game.

A 16.5-point spread is a bit too wide for my liking, though, so I’ll take the Over on the 38.5-point total considering that the Cowboys surpassed that number alone in Week 1.

Giants vs Cowboys Prediction: DAL wins

Giants vs Cowboys Best Bet: o38.5 Total Points (-110)

Commanders vs Seahawks Odds

The Commanders head into Week 10 following a hard-fought 20-17 win over the Patriots. Meanwhile, the Seahawks will hope for better results after getting embarrassed by last week’s 37-3 loss against the Ravens.

Even though their latest outing was disappointing, the Seahawks are still 3-0 in their last three home games. The Commanders are also allowing the sixth-most passing yards in the league, making it the perfect game to help Seattle’s Geno Smith get back to last season’s form.

Nevertheless, the Commanders do have the 12th-best road scoring margin, so I won’t be shocked if they keep things closer than the 6-point spread implies. It also helps that Washington is 4-2 ATS in its last six meetings with Seattle.

Commanders vs Seahawks Prediction: SEA wins

Commanders vs Seahawks Best Bet: WAS +6 (-105)

NFL Week 10 Sunday Night Football Predictions

Jets vs Raiders Odds

The Jets’ three-game winning streak came to a halt with a 27-6 loss to the Chargers in Week 9. Meanwhile, Antonio Pierce earned a win in his NFL head coaching debut as the Raiders pounded the Giants to the tune of a 30-6 final score.

The Jets’ defense has been phenomenal this season, so I’m chalking up their blowout loss to a fluke instance. I’m also willing to go out on a limb by classifying Pierce’s debut win as a fluke, too, given that the Raiders faced the Giants — arguably, the worst team this season.

Let’s take the Jets to beat the Raiders, who’ve yet to beat a team with a winning record in 2023.

Jets vs Raiders Prediction: NYJ wins

Jets vs Raiders Best Bet: NYJ -2 (-110)

NFL Week 10 Monday Night Football Predictions

Broncos vs Bills Odds

The Broncos have shown signs of life lately, most recently landing a 24-9 upset victory over the Chiefs last week. The Bills, on the flip side, have seen better days, left looking to rebound from a 24-18 loss to the Bengals.

— Mitch Goldich �� (@mitchgoldich) November 7, 2023