NFL Week 4 Odds: Spreads, Moneylines, Totals, Betting Insights

Oddsmakers have released opening lines for NFL Week 4. Tampa Bay Buccaneers host the Kansas City Chiefs on Sunday Night Football. The defending champion LA Rams visit the San Francisco 49ers on Monday Night football.

Miami Dolphins are top of the AFC East. They beat Buffalo in Week 3. Cincinnati Bengals won against New York Jets 27-12. Joe Burrow will have to deal with a high-powered Dolphins passing offense.

Minnesota Vikings beat Detroit Lions in Week 3. Dalvin Cook left the game with a shoulder injury. Jameis Winston threw two more interceptions in the Panthers' loss. New Orleans Saints are 1-2 and travel to the UK to play the Vikings.

Cleveland Browns are a road favorite against Atlanta Falcons. Jacoby Brissett has been good for the Browns, while the running backs have gashed the opposition on the ground. Atlanta won their first game of the year in Week 3 against Seattle.

Washington's offense sputtered against the Eagles in Week 3. The Cowboys play on Monday night against Giants.

Seattle has lost two games in a row. Detroit has won two of three games this season. Seattle has only won one game this year. Geno Smith threw for 325 yards and two touchdowns against the Falcons in Week 3.

Tennessee and Indianapolis are going to play each other in the AFC South. Indianapolis stunned the Chiefs as five-point home underdogs in Week 3. The Titans finally found a way to get Derrick Henry involved in their offense in week 3 against the Raiders.

The Giants are favored again, but the underlying numbers tell a different story. The Giants have looked underwhelming this season. They play the Cowboys on Monday Night Football.

The Jaguars are looking feisty on defense. The entire Jags roster looked dominant in a 38-10 win over the Chargers. Philadelphia is seven-point favorites.

Jets lost to the Bengals in the last game. Zach Wilson is expected to return for the Jets next week. The Steelers get extra rest after losing 29-17 to Cleveland on Thursday Night Football.

Buffalo Bills lost 21-19 to Miami in Week 3. The Bills are favored again against the Ravens. Baltimore beat New England in the previous game.

The Chargers started Justin Herbert against the Jaguars. He was ineffective. Los Angeles has several injuries on both sides of the ball. The Texans played another close game against Bears but fell short. They are 3-0 against spreads this season.

Baker Mayfield is completing 50% of his passes and has only three touchdowns. Kyler Murray threw the ball 58 times against the Rams in Week 3. The Panthers defense led the way in a 22-14 home win against New Orleans.

Mac Jones left the game against the Ravens with an ankle injury. Brian Hoyer would replace him if he can't play. The Packers defense looked ferocious again in Week 3, holding Tom Brady and the Bucs to 12 points scored on 4.8 yards per play, so the spread should stay well above a touchdown.

Denver Broncos and Oakland Raiders are playing in the AFC West. The Raiders' offense continues to struggle. Denver won at home against the 49ers on Sunday Night Football.

The Chiefs lost to the Colts in Week 3. The last time the teams met, the Buccaneers won 31-9. They will present a tough test for Patrick Mahomes.

Rams and 49ers are playing on Monday Night Football. Rams beat the 49er 20-17 in the NFC Championship Game last year.