Padres vs. Giants odds, line, prediction: 2022 MLB picks, April 12 best bets from proven computer model

The San Francisco Giants and San Diego Padres are playing each other on Tuesday at 9:45 p.m. ET. The Padres won the first game of the three-game series 4-2. Alex Cobb is making his first start for San. Francisco. Yu Darvish is getting the start. San San Antonio is a -115 favorite on the money line.

SportsLine's model has revealed its predictions and best bets for Padres vs. Giants. San Francisco Giants are 4-1 in their last 5 Tuesday games. The Padres are unbeaten in four of their past five road games and are favored by 1.5 runs.

Padres vs. Giants is a game on April 12. San Diego is 4-0 in their last 4 road games. The Giants are 4 of their 5 Tuesday games this season.

Jurickson Profar has a .357 batting average with two home runs and seven runs batted in. Manny Machado has good power and a tremendous arm. He has recorded at least one hit in four straight games.

Brandon Belt has a batting average of .417 with one home run and one RBI. San Francisco has been solid on the pitching mound, and they haven't allowed 4-plus runs in three straight games. Alex Cobb is making the start for the Giants.

SportsLine's computer model is leaning over on the run total. It also says one side of the money line has all the value.