Real Madrid vs. Manchester City prediction, odds: Expert reveals 2022 Champions League picks for April 26

Manchester City is the favorite against Real Madrid in the first leg of their UEFA Champions League semifinal on Tuesday at 3 p.m. ET. Real is a +500 underdog. The over-under for total goals scored is 2.5. Brandt Sutton is SportsLine's top soccer editor. He factors in managerial tactics, projected lineups and past performances to make his picks.

Manchester City and Real Madrid meet on April 26. The game is a 2.5-goal favorite. Manchester City have scored 10 goals in their last three matches. Real have netted at least two goals six times in a row.

Manchester City and Real Madrid meet on April 26. The Cityzens have scored 10 goals in their last three matches. Los Blancos have netted at least two goals six times in a row.

Manchester City is looking for another big performance from Gabriel Jesus. The team has outscored its opponents 24-10 during Champions League play. Manchester City has received goals from 11 different players in the tournament. Riyad Mahrez tops the club with 23 goals in 42 matches across all competitions.

Real Madrid hasn't been held under two goals since March 20. Los Blancos have scored at least two in seven of their last eight Champions League games. Karim Benzema leads the team and is second overall in the Champions league with 12 goals. Rodrygo has netted three goals during Champions' League play, while Vinicius Jr. has scored twice and has six assists.

Sutton has analyzed the Real Madrid vs. Manchester City match from all sides and he's going over on the goal total. He also provides another confident best bet and has a full breakdown of the match.