Sheffield United vs. Manchester United odds: English Premier League picks, Oct. 21 prediction from proven soccer insider

Sheffield United will square off against Manchester United at 3 p.m. ET on Saturday at Bramall Lane. Sheffield United are 0-1-7 overall and 0-1-3 at home, while Manchester United are 4-0-4 overall and 1-0-2 on the road. The latest Manchester United vs. Sheffield United odds list Manchester United as the -250 favorite (risk $250 to win $100) on the 90-minute money line, with Sheffield United the +600 underdog. A draw is priced at +410, and the over/under is 2.5 goals.

Before entering any Sheffield United vs. Manchester United picks, you'll want to see the EPL predictions from SportsLine's soccer insider Jim Holliman.

Holliman has been a writer and editor for nearly 25 years and grew up with soccer in his blood. He played competitively through high school and has been following the game closely since the 1970's heyday of the North American Soccer League. His interest has expanded worldwide, and his betting approach is centered on crunching the numbers, but he sees the whole field and relies on his instinct.

Since the 2022 World Cup, Holliman has been profitable across multiple leagues, including the Premier League, UEFA Champions League and Bundesliga. He went 21-10 -- bringing a profit of $1,147 for $100 bettors -- on his Champions League predictions last season.

The expert has taken an in-depth look at the Sheffield United vs. Manchester United showdown and has locked in his most confident best bets. You absolutely need to see his picks before making any selections of your own.