Spurs vs. Pacers odds, line, spread: 2022 NBA picks, Oct. 21 predictions from proven computer model

The San Antonio Spurs lost to Charlotte on Friday night. They play the Indiana Pacers on Saturday at 7 p.m. ET. Indiana is a 1-point favorite in Caesars Sportsbook's latest Pacers vs. Spurs odds. The over/under is set at 232. SportsLine's advanced computer model simulates every NBA game 10,000 times and has returned well over $10,00 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons.

SportsLine's computer model has picked Spurs vs. Pacers. The model is using its advanced statistics to make its picks.

Spurs vs. Pacers is a 2022 NBA game. The line is Indiana -1. Spurs vs Pacers over/under is 232 points.

Indiana lost its season-opening game against Washington by seven points. San Antonio lost by 27 points to the Wizards. The Pacers beat San Antonio in both meetings last year. Indiana has covered the spread in 10 of the last 12 games between these teams.

Spurs are the favorite against the Pacers. Myles Turner is out for the game with an ankle injury. The Pacers have lost 11 straight games. San Antonio has covered the spread at a 9-3-1 clip in their last 13 games, while Indiana has only covered three times in its last nine games against Western Conference teams.

The model simulates Spurs vs. Pacers 10,000 times and it's leaning Over. It also generated a point-spread pick that's hitting in well over 50% of simulations.