West Virginia vs. Virginia Tech odds, prediction: 2022 Week 4 college football picks by model on 51-43 run

West Virginia is 2-point favorite against Virginia Tech in 2022 college football game. The Mountaineers are looking for their second road win in the all-time series in 30 years. VirginiaTech is on a two-game winning streak. SportsLine's computer model simulates every FBS college game 10,000 times and has returned a profit of more than $3,300 for $100 players on its top-rated college basketball picks.

West Virginia vs. Virginia Tech is a college football game on September 14th. The Mountaineers are 4-1 against the spread in their last five non-conference games. After a straight-up win, the Hokies are 1-11 ATS in the last 12 games following a win.

West Virginia vs. Virginia Tech is a Week 4 college football game. The Mountaineers are 4-1 against the spread in their last five non-conference games.

Tony Mathis Jr. and CJ Donaldson both ran for more than 100 yards and scored five touchdowns in the rout. Four different quarterbacks played for the Mountaineers on Saturday. West Virginia gained 316 yards on the ground and 308 through the air.

Virginia Tech's defense is ranked third in the nation against the run. The Hokies limited Wofford to just 38 rushing yards on Saturday. Quarterback Grant Wells completed 26-of-35 pass attempts for 314 yards and a pair of touchdowns.

SportsLine's model is leaning Over the total and has generated an against-the-spread pick that cashes in well over 50% of simulations.