White Sox vs Guardians Betting Preview, Prediction and Odds Sept 22

Eric Pauly is a Sportsmemo MLB handicapper. Eric Pauley gives his analysis of Thursday's Chicago White Sox vs Cleveland Guardians clash at Guaranteed Rate Field. This will be the 19th and final game played between the White Sells and Guardians this regular season.

The Guardians and the White Sox are playing the third and final game of a three-game series on Thursday night. The Guardians are -140 road favorites.

Cleveland is 6 games ahead of Guardians in the AL Central. Guardians are 4-1 in their last 5 games and are 82-67 on the season. Shane Bieber will start for Guardians against Chicago. Bieber is 11-8 with a 2.83 ERA, a 1.03 WHIP, and a2.84 FIP this season, but he is 2-2 against the White Sox.

Johnny Cueto will take the mound for the White Sox tonight at home. On the season, Cueta is 7-8 with a 3.09 ERA, a 1.20 WHIP, and a3.95 FIP. In his last start, he allowed five runs on eight hits in 4.2 innings of work.

The White Sox are playing against the Guardians on September 22. The game is on the moneyline.

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White Sox vs Guardians Betting Preview, Prediction and Odds Sept 22. Latest Betts Oddings and Public Action: Vegas lines updated in real time. Free Sports Picks and Best Bets from our team of expert sports handicappers.