NFL Betting: Week 6 Best Picks and Advice

Stadium sports betting analyst Nate Jacobson breaks down every NFL game's point spread using lines as of Thursday morning.

Green Bay Packers lost to the Giants last week. They are a 7-point favorite against the Jets. The Jets are 2-0 with Zach Wilson as their starter. New York beat the Steelers and Dolphins. The score against Miami was only 19-17 entering the fourth quarter. A missed field goal attempt gave the Dolphins a chance to take the lead.

Colts are 2-2-1 after 5 games. They were beaten 24-0 by the Jaguars in Jacksonville four weeks ago. The Colts have a bye week. Frank Reich's team has started slow in the past. Jaguars lost as touchdown favorites to the Texans. Jaguars were the favorite in early season, but they lost to Eagles.

Saints are the underdogs against Bengals. The Bengals lost the Sunday night game 19-17 to the Ravens. New Orleans won last week but their defense gave up 8.1 yards per play to Seahawks. There are injury questions surrounding the Saints, including the health of QB Jameis Winston and their top-three WRs.

Ravens are a smart bet when they step down in class. They have the ability to win by margin even on the road. I expect Lamar Jackson to have a big game against a Giants team that is getting too much respect and due for a letdown.

Panthers are the favorite to cover the 10-point spread against Rams. Baker Mayfield is injured and PJ Walker will start for the Panthers. The Rams are struggling and I don't trust them to win.

Seahawks are a home favorite at +3 over Cardinals. Seattle has played well on offense the last three games. Arizona's defense isn't a step up in class.

The Chiefs are a home favorite at Arrowhead Stadium against the Bills. The Chiefs have won the last two games in Kansas City. Buffalo has had regular-season success at the Arrowheads. The Bills were a 3.5-point favorite against Baltimore two weeks ago.

Eagles are 5-0 and the Cowboys are 4-1. Cooper Rush will start for the Eagles. The Cowboys won last week against the Rams. Eagles have some offensive line injuries. If they are healthy, they should be able to neutralize Dallas’ defensive front.

Broncos are favored to beat the Chargers at +4.5 on Sunday night. The team has seen the Broncos offense three times in primetime. Russell Wilson flew to LA after Thursday's game to receive an injection to help with his injured shoulder.

Commanders are 1-4 on the season and lost to the Titans last week. Commanders play Bears on Thursday.

Buccaneers are the underdogs at Steelers. It was Kenny Pickett's first start for the Steelers last week. He should play better at home in the stadium he played college football in.

Patriots are playing without their starting quarterback. They beat the Lions 29-0 last week. The Patriots are taking on the Browns this week, who are also without a starting QB. Vikings are going to play the Dolphins, despite Teddy Bridgewater's concussion. Skylar Thompson will start for the Vikings this time.

49ers are playing at The Greenbrier in West Virginia this week. They are 4-0 in the second road game. The 49ers have injuries and they have two big games against the Chiefs and Rams coming up.