NFL odds, lines, point spreads: Updated Week 16 betting information for picking every game

Similar to Week 14, favorites did their part in winning straight up (12-4 SU) in Week 15, but underdogs continued to cash spread tickets (10-4-1 ATS). In Sunday's early-afternoon session, all six underdogs covered the spread, but favorites bounced back in the late-afternoon slate, posting a 3-0-1 ATS mark. Will the 'dogs continue to bark in Week 16?  As we do at the start of each week, we'll list every game's spread, moneyline, and total, updating those numbers as they get bet throughout the next few days.

Week 16 looks a bit different, as we have an 11-game slate on Saturday, highlighted by Cowboys-Eagles, Chiefs-Seahawks, Patriots-Bengals, and 49ers-Commanders. As usual, the action kicks off on Thursday night when the surging Jaguars take on the Jets at MetLife Stadium. Following Saturday's 11-game slate, the action continues on Christmas with a three-game slate (Dolphins-Packers, Rams-Broncos, Cardinals-Buccaneers) that will hopefully result in some winning tickets for bettors to enhance their holiday.

Keep in mind these lines will move throughout the week as we get updates on various injuries and betting limits increase. Below, we take a look at the latest odds for Week 16 from BetMGM and offer up a few early bets to consider.

NFL odds Week 16

NFL moneylines Week 16

NFL over/unders Week 16

NFL best bets for Week 16

*Odds as of Monday 12/19*

Bills -8.5 (-110) at Bears

I tend to refrain from betting on hefty road favorites, but Buffalo is more than capable of notching a double-digit victory in Chicago on Christmas Eve. The Bears most recently closed as 8.5-point road underdogs against the Eagles in Week 15, and although they covered, Philadelphia didn't even play its best game and still had a chance to notch the cover. Jalen Hurts tossed two interceptions in the first half while the Eagles mustered just 10 points against a Bears defense allowing the highest EPA/play (+0.102 EPA). The Eagles put it together in the second half and led by 12 with 4:20 left in the fourth, but Justin Fields found Byron Pringle on a 35-yard TD pass to notch a backdoor cover. As long as Josh Allen avoids turnovers, tickets with Bills' -8.5 should cash. Buffalo's offense is right behind Philadelphia in terms of EPA/play (+0.112), and there's a real chance it drops 30-plus points on Chicago.

Browns-Saints OVER 33.5 (-110)

If this game closes at 33.5 or lower, it will be the lowest total of the season. While it's tough to rely on Deshaun Watson and Andy Dalton to generate offense, especially with snow showers in the forecast, seeing a 33.5 total in today's NFL is almost unheard of. We'll brave the elements and hope for a defensive score or two coupled with some good starting field position from both teams that will translate into at least 34 points.

Buccaneers -4.5 (-110) at Cardinals

Not many are rushing to the window to bet on the Buccaneers after their second-half collapse against the Bengals, but I'll hold my nose and lay the points here. Assuming Colt McCoy (concussion) is ruled out and Trace McSorley starts, the Buccaneers are capable of notching a TD-plus road win in prime time. Tampa's turnovers and lack of execution allowed Cincinnati to score 34 unanswered points, but I'm chalking up those turnovers to flukiness. Arizona's offense won't stress Tampa's defense like Cincinnati did, and Tampa can remain in first place in the NFC South with a road win and cover.