San Francisco 49ers vs Seattle Seahawks Odds, Lines, Picks and Predictions for Week 15 Thursday Night Football

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San Francisco 49ers vs Seattle Seahawks Odds, Lines, Picks and Predictions for Week 15 Thursday Night Football

49ers QBs to end the regular season:1. Brock Purdy2. Josh Johnson

(Jimmy Garoppolo in a state of limbo)

— Matt Barrows (@mattbarrows) December 13, 2022

What can Purdy do for an encore? Well, he could be leading the 49ers to the division title with a victory in this game.

San Francisco kept its offensive gameplan simple against Tampa Bay. The 49ers relied heavily on the run game, riding Christian McCaffrey (14 carries, 119 yards).

Seahawks In A Funk

Is Geno Smith’s Cinderella season turning into a pumpkin? Four of the eight picks thrown by the Seahawks QB have come in the last three games. Seattle is 1-3 SU and 0-4 ATS in the past four games.

San Francisco’s run-first philosophy should also work against a Seattle defense that was carved up for 223 yards on the ground last week by the Carolina Panthers. The 49ers rambled for 189 yards rushing in their first game against Seattle this season. That was prior to acquiring McCaffrey.

Samuel Out For 49ers

Both clubs are showing some key names on the respective injury lists. For the 49ers, WR Deebo Samuel (ankle) and LDT Kevin Givens (knee) are out. Purdy (oblique), McCaffrey (knee), and RDT Aric Armstead (foot) are listed as questionable.

Seahawks RB Kenneth Walker III, the +260 second betting choice in the NFL OROY odds, was out last week with an ankle injury. But he’s given no injury designation for this week. However, on defense, NT Al Woods (Achilles), WLB Bruce Irvin (knee) and SS Ryan Neal (knee) are questionable.

49ers vs Seahawks Prediction

Only three NFL teams are better ATS bets this season than the 49ers. Seattle is 3-3 ATS at home this season.

Seattle needs to win this game. Not only to still be in with a chance to win the NFC West, but to regain a grasp on a Wild Card playoff spot.

Getting points on a home team is always a good thing. And to make it even better, the Seahawks are 2-0 ATS as a home underdog this season.

  • Pick: Seattle Seahawks +3 (-110)
  • TNF record (0-0 ML, 6-7 ATS, 1-0 O/U)