Titans vs. Jaguars prediction, odds, line, spread: 2023 NFL picks, Week 18 best bets from model on 160-113 run

The Tennessee Titans host the Jacksonville Jaguars on Saturday at 8:15 p.m. ET. The winner will claim the AFC South title. Caesars Sportsbook lists Jacksonville as a 6.5-point home favorite. Over/under is 40 in the latest Titans vs. Jaguars odds. A model on the NFL PickWatch website has been very accurate in its predictions for the 2022 season.

Titans vs. Jaguars is a Week 18 NFL game. The Jaguars are favored by 6.5 points. Titans are 5-2-1 against the spread in road games and 4-3-0 against spread at home.

Titans are 5-2-1 against the spread in road games and 4-4-0 against against in home games. Jaguars are 4.2 against a spread of 6.5.

Titans are well-coached under Mike Vrabel and have a well balanced team. The Titans are above-average in scoring defense and are elite against the run. Ryan Stonehouse leads the NFL with 53.0 yards per punt.

Jacksonville has the more explosive offense and a better defense. The Jaguars are a top-five team in creating turnovers (25) and taking a takeaway on 14.1% of defensive possessions. Tennessee's offense is weakened without quarterback Ryan Tannehill. Titans haven't scored 28 points or more in any game this season.

The model simulates Saturday's Titans vs. Jaguars game 10,000 times and picks one side of the spread that cashes well over 50% of time. SportsLine's model is leaning Under the total.