2021 MLB playoffs: Red Sox vs. Astros odds, line, ALCS Game 6 picks, predictions from proven computer model

Boston Red Sox are on the brink of elimination in the 2021 ALCS against the Houston Astros. Nathan Eovaldi, who grew up in Houston, will take the mound for Boston. Luis Garcia will start for Houston. The model simulates every game 10,000 times and has a 207-176 record on top-rated MLB money-line picks.

SportsLine's model has revealed its coveted picks and predictions for Houston Astros vs. Boston Red Sox. Houston is a money line favorite at -111, while Boston is +101. Kyle Tucker and Kike Hernandez are tied for the MLB lead in RBI in the playoffs (12).

Houston and Boston are playing each other in the playoffs. Houston is one of the favourites.

Houston has arguably the deepest lineup in baseball. Jose Altuve, the 2017 MVP, leads off. Michael Brantley, Alex Bregman, Carlos Correa, Kyle Tucker and Yuli Gurriel are batting second. The Astros pitchers have done a good job against the Red Sox bats in the last two games.

Garcia left the Game 2 game with knee discomfort. He has a 24.55 ERA in two postseason starts this season. Kike Hernandez is on a run in the postseason, batting .474 in his last eight games.

SportsLine's model is leaning over on the run total and says one side of the money line has all the value. SportsLine is only showing its model's Red Sox vs. Astros pick at Sportsline.