2022 MLB Opening Day odds, picks, lines, best bets from proven model: This four-way parlay pays almost 15-1

The Atlanta Braves are defending their World Series title on Thursday when they host the Cincinnati Reds. First pitch is 8:08 p.m. ET. The game is one of seven scheduled for Opening Day. Other games include the reigning AL champion Astros taking on reigning MVP Shohei Ohtani and the Angels taking against the Brewers. SportsLine's advanced computer model simulates every game 10,000 times. It returned more than $700 to players following its moneyline picks in 2021.

The model simulates every Opening Day game 10,000 times and likes Houston to beat Los Angeles. The Astros have won the AL West in four of the last five seasons. Los Angles has not reached the postseason since winning the division in 2014.

The model has selected a four-way parlay with a payout of almost 15-1. It also has three other best bets for Opening Day.