2022 U.S. Open Men's Odds, Picks & Betting Predictions

The US Open starts on Monday, August 29. The tournament is the fourth grand slam of the season. Daniil Medvedev is defending champion. Rafael Nadal is a two-time champion at the US open. Novak Djokovic is absent. Alexander Zverev is injured. Stefanos Tsitsipas, Casper Ruud, Pablo Carreno Busta, Borna Coric, Jannik Sinner and Taylor Fritz are young players who could make their breakthroughs at this year's USopen.

The reigning World No.1 is embarking on his first major title defense. He is the top favorite according to the tennis betting markets. Felix Auger Aliassime and Carreno Busta are on a collision course for a quarterfinal bout. Nick Kyrgios is a potential fourth-round opponent. Stefan Kozlov and wild card Ben Shelton could also pose problems for Medvedev.

Nadal lost to Coric in the second round of Cincinnati. He is seeded No.2 and will open his campaign against wild card Rinky Hijikata. His section looks very favorable with Cameron Norrie as the 2nd-highest seed. Diego Schwartzman, Miomir Kecmanovic and Francis Tiafoe are the top seeds in his area.

Alcaraz is the third-best bet entering this year's US Open according to the best sportsbooks. The 19-year-old won ATP Masters 1000 titles and became the first player to beat both Nadal and Djokovic on clay in the same tournament. Alcaroz has had mixed results since the start of the American hard-court swing, crashing out of Montreal in his first match and reaching the quarters of Cincy.

Kyrgios enjoyed his major breakthrough at Wimbledon. He will play Thanasi Kokkinakis in the first round of the U.S. Open.

Tsitsipas is the second-highest seed. He is paired with Casper Ruud and Matteo Berrettini. Berretini and RuUD could meet in the R16. Tommy Paul and Taylor Fritz could also be in his way. Tsitsipsi could face Lorenzo Sonego, Yoshihito Nakashima or Alexander Davidovich-Fokina in early rounds.

Taylor Fritz and Tommy Paul are the top American bets for 2022 US Open. They fall into Tsitsipas' quarter and could meet in the fourth round. Paul could also face Sebastian Korda in second round, if they both make it.

The US Open draw is stacked with American hopefuls. John Isner is in the best position to capitalize in Norrie’s section of the fourth quarter.