76ers vs. Pistons odds, line: 2022 NBA picks, Dec. 21 predictions from proven computer model

The Philadelphia 76ers (17-12) are on a five-game winning streak. They face the Detroit Pistons (8-25) on Wednesday at 7 p.m. ET. Philadelphia is favored by 11.5 points in the latest 76er vs. Pistons odds. The over/under is set at 222.

SportsLine's computer model has picked Philadelphia 76ers vs. Detroit Pistons. The model is using its advanced computer simulations to make its picks.

Philadelphia is on a five-game winning streak and 10-1 in their last 11 home games. Tobias Harris has been hot during this streak, making multiple 3-pointers in six consecutive games and has a lot of confidence. Detroit lost star guard Cade Cunningham to a season-ending injury and is 6-6 in the last 7 games, but has won 11 of the past 13 meetings.

Detroit Pistons are losing games, but they have covered the spread in seven of their last eight road games. They also pulled off an upset at Miami as 7.5-point underdogs two weeks ago. Philadelphia is dealing with a key injury, as guard Tyrese Maxey will remain sidelined on Wednesday due to a foot injury.

The model simulates 76ers vs. Pistons 10,000 times and it's leaning Over. It also says one side of the spread hits over 50% of time.