Chicago Cubs at Pittsburgh Pirates odds, picks and best bets

Chicago Cubs clinched a playoff berth on Tuesday night. They will play Pittsburgh Pirates at PNC Park on Wednesday at 7:05 p.m. ET.

Kyle Hendricks and Trevor Williams are the starting pitchers for the Chicago Cubs and Pittsburgh Pirates. Hendricks has been a stud this year, going 6-4 with a 2.93 ERA. Williams has struggled recently, with one win in 10 starts and a 9.59 ERA, and the Pirates are 1-9 in his starts this season.

Hendricks has a 1.21 ERA in four starts this month. He is 6-7 with a 3.08 ERA against the Pirates in 18 career starts.

Williams has struggled in his last five starts, allowing 11 home runs with a 9.59 ERA. The Pirates are 1-9 in Williams starts this year, with their only win coming on August 13 against the Reds.

Anthony Alford, Cole Tucker, Keone Kela, Jason Martin and Jason Martins are out for Chicago Cubs at Pittsburgh Pirates.

The Cubs are heavily favored over the Pirates despite losing Tuesday's game. Chicago has already clinched a playoff berth. Pittsburgh's games have been going under more often than not. The total has gone under in six of the last seven road games and in five of last six games overall. The Pirates have won six out of their last nine games.