Cubs vs. Pirates odds, line, prediction: 2022 MLB picks, April 13 best bets from proven computer model

The Chicago Cubs are looking to complete a two-game sweep of the Pittsburgh Pirates. Chicago won the first game 2-1 on Tuesday thanks to two home runs from Seiya Suzuki. Pittsburgh avoided being shut out for the second time in four games this year with a solo homer from Bryan Reynolds. First pitch is at 12:35 p.m. ET.

Cubs vs. Pirates is a game on April 13. Chicago is the favorite. Pittsburgh is favored by 110 points. The game is worth 1.5 runs. Yan Gomes is 2-for-2 lifetime against Thompson. Current Pirates are hitting a combined .153 versus Chicago's Kyle Hendricks.

Cubs vs. Pirates money line is Chicago -130, Pittsburgh +110. The game is over-under 8.5 runs. Yan Gomes is 2-for-2 lifetime against Thompson. Current Pirates are hitting a combined .153 versus Chicago's Kyle Hendricks.

Suzuki is off to a good start in his first season in the majors. Ian Happ is also off the mark at the plate. Kyle Hendricks will start for the Cubs. He pitched well against Milwaukee on Opening Day. He allowed one run and five hits with seven strikeouts over 5 1/3 innings.

Thompson was acquired from Miami in a four-player deal. He was a rookie with the Marlins last year and went 3-7 with a 3.24 ERA. Ke'Bryan Hayes is expected to improve at the plate this season. Hayes got off to a good start in Pittsburgh's first series of 2022 at St. Louis.

SportsLine's computer model is leaning over on the total. It also says one side of the money line has all the value.