Chicago White Sox vs. Cleveland Guardians Odds, Line, Picks, and Prediction

The Chicago White Sox are playing the Cleveland Guardians on Wednesday (September 21) night. The Guardians are 5 1/2 games behind the White Sells in the American League Central race. Cleveland won 10-7 against Chicago on Tuesday. Chicago is 76-72 and 5 games back in their race for the final American league wild card spot. Lance Lynn is the starting pitcher for Chicago. Triston McKenzie is starting for Cleveland.

Chicago White Sox play against Cleveland Guardians.

Chicago White Sox play Cleveland Guardians on Wednesday, September 21 at 8:10 p.m. EDT at Guaranteed Rate Field.

Chicago White Sox vs. Cleveland Guardians is a betting match.

Chicago White Sox and Cleveland Guardians have been playing well recently. Last month's game ended 5-2 in favor of Cleveland.