College Football Upset Picks, Predictions: 5 Teams on Disaster Watch for Week 10

There are more games this week, so bettors have more chances to correctly predict upsets. Last week's predictions fell short. Here are the top college football upset picks for Week 10. The picks are via SuperBook, DraftKings Sportsbook, and FanDuel Sportsbooks.

Duke, Boston College, Air Force, Army, West Virginia, Iowa State, UCF, Memphis, UNLV and San Diego State are the college football upset picks for Week 10.

Duke vs. Boston College is a big favorite. Air Force vs Army is also a favorite, as is West Virginia vs Iowa State and UCF vs Memphis.

There are five teams on Disaster Watch for Week 10.

Boston College has only one win over FBS opposition and was stymied by UConn last week. The Eagles beat Louisville several weeks ago in an upset. Boston College's offense has been bad for much of the year, but it came to life against Louisville. Zay Flowers and Phil Jurkovec are expected to do damage against a vulnerable Duke defense.

Army is a 7.5-point underdog against Air Force. Jeff Monken's team has gone 4-1 both straight-up and against the spread in the last five editions of this annual rivalry. Army has been awful at stopping the run this season, but they have a better chance of holding their own against a fellow service academy.

West Virginia is among our college football upset picks for the second week in a row. The Mountaineers are on the road against Iowa State, who are a combined 1-9 in Big 12 play. Iowa is a heavy favorite, but the Mountaines' poor defense could be enough to give them a chance.

Memphis is a plus-140 favorite at home against UCF. UCf is ranked 25th in the CFP rankings. Memphis is on a losing streak. Tulane is 19th and unbeaten in AAC play. Tulain is also a 3.5-point favorite.

UNLV has lost three straight games by a combined margin of 91 points. Doug Brumfield is expected to start for the Rebels against San Diego State. UNLV is a +225 favorite. SanDiego State is ranked 127th out of 131 teams in adjusted offensive efficiency.

College football upset picks are made 11/03/2022 at 3:16 p.m. ET.