Colorado vs. Arizona State spread, odds, line, game props: Expert picks, Deion Sanders predictions, bets

Coach Deion Sanders and the Colorado Buffaloes (3-2) look to get back on track when they travel to the desert to take on the Arizona State Sun Devils (1-4) on Saturday. The Buffs have dropped two straight games -- to No. 8 Oregon in Week 4 and No. 9 USC in Week 5 -- but have one of the best quarterbacks in the country in Shedeur Sanders. The Sun Devils have dropped four straight including a 24-21 loss to Call last week. CU is 3-2 against the spread under Coach Prime, while ASU is 2-2 ATS this season under first-year head coach Kenny Dillingham. Travis Hunter (liver) remains out for CU, while safety Shilo Sanders (kidney) is listed as questionable.

Kickoff is set for 6:30 p.m. ET at at Mountain America Stadium. The latest Arizona State vs. Colorado odds via SportsLine consensus list the Buffaloes as 3.5-point favorites, which is down two points from the opening Colorado vs. ASU line (-5.5), with the over/under at 59. Before making any Colorado vs. Arizona State picks or bets, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, going 11-3 on his best bets in the Buffs' first five games, including a 5-1 mark in the CU vs. USC game. He's also 18-3 on all of his CFB best bets for SportsLine this season so far. Anyone who has followed his picks is way up.

Now, he has set his sights on Colorado vs. Arizona State and just locked in its picks and CFB predictions. You can head to SportsLine now to see Kaylor's picks. Here are several college football odds and betting lines for Arizona State vs. Colorado:

• Colorado vs. Arizona State spread: Colorado -3.5
• Colorado vs. Arizona State over/under: 59 points
• Colorado vs. Arizona State money line: Colorado -174, ASU +145
  
• CU: QB Shedeur Sanders is averaging 356.2 passing yards per game. 
• ASU: RB Cameron Skattebo has 318 rushing yards and 4 TDs.
• Colorado vs. Arizona State picks: See picks at SportsLine
  
• Colorado vs. Arizona State live stream: fubo (try for free)

Why Colorado can cover

Colorado is led by a Heisman Trophy contender in Shedeur Sanders. The junior quarterback has been outstanding in his first season at the FBS level, and nearly guided Colorado to a monumental comeback last week against USC. He enters this matchup with 1,781 passing yards, 15 TD passes, two interceptions and two rushing TDs.

The Buffs also have a plethora of options at wide receiver for Sanders to spread the ball around to. Last week, true freshman Omarion Miller caught seven passes for 196 yards and a touchdown. He joins veterans Xavier Weaver (41 catches, 490 yards, 2 TDs) and Jimmy Horn Jr. (34 receptions, 327 yards, 4 TDs) as Sanders' top targets. See which team to pick at SportsLine. 

Why Arizona State can cover

The Tempe desert and Mountain America Stadium can be a difficult place to play for opposing teams. The Sun Devils have covered the point spread in two straight games, and should have extra motivation with Coach Prime bringing the national spotlight to their home field. ASU has dropped four straight, but has shown signs of improvement over the last two weeks. 

Junior running back Cameron Skattebo has been effective out of the backfield for Arizona State. He enters this matchup with 318 rushing yards and four touchdowns, and 14 catches for 228 yards and a TD. He will be facing a Colorado defense that gives up 184.2 rushing yards per game. See which team to back at SportsLine. 

How to make Arizona State vs. Colorado picks

Kaylor has analyzed this matchup from every angle and he's going Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.