Cowboys vs. 49ers Predictions, Picks, Odds Today: Dak Prescott, CeeDee Lamb, Christian McCaffrey, and More
It’s the Game of the Week on Sunday Night Football — the Dallas Cowboys travel to the Bay Area to take on the San Francisco 49ers, the team that has ended their season two years in a row.
Through four weeks, these are two of the most dominant teams in the NFL. Cowboys vs. 49ers features two teams with the highest point differentials in the NFL this season and the two best in the NFC. Perhaps this is a preview of another playoff battle between these two teams, and maybe even an NFC Championship.
Will the Cowboys get revenge tonight, or will the 49ers remain unbeaten? PFN’s betting team gives their Cowboys vs. 49ers predictions, picks against the spread, favorite player props, and more.
Our Betting Lines page has the freshest lines and promos to get BANG for your buck. PFN’s FREE Parlay Calculator and Betting Odds CalculatorHow to Bet on the NFL. Visit our Sports Betting Legal Tracker on how to bet legally in the U.S.
Dallas Cowboys vs. San Francisco 49ers Betting Lines, Start Time, and More
All odds are from DraftKings Sportsbook unless stated otherwise.
- Spread
49ers -3.5 - Moneyline
Cowboys +150, 49ers -180 - Over/Under
45 - Game Time
8:15 p.m. ET - Location
Levi’s Stadium - How To Watch
NBC, Peacock
Bearman: It might be time to admit I was too low on the Niners this season. They are the real deal, with an offense putting up 31.3 PPG (only behind Miami and Buffalo) and a defense holding their opponents to 14.5 PPG (behind Dallas and Buffalo).
You can doubt if Kyle Shanahan can get it done in February, but there are no longer questions about how good this team is. Purdy is good enough to get it done, and they might be the best team in football.
As for Dallas, I am still not sold on them yet. This game will go a long way toward possibly changing my mind. I don’t use the transitive approach often, but both teams did just play the Cardinals, with the Niners never really being challenged and the Cowboys never really being in the game in their loss.
The hook on the side is bothersome, but I am going to spend the 24 cents and put it down.
Pick: 49ers -3 (-124 at SugarHouse)
Blewis: Getting three points plus the hook with the Cowboys is very intriguing, but they have struggled in this matchup in recent years, and it almost seems like a trap line, considering it hasn’t moved. So, I’ll go in a different direction instead.
This Cowboys defense has been the 2nd-best unit by EPA/play this season behind the Browns, but if there’s one weakness for them, it’s stopping the run, ranking 27th in success rate. Their run defense hasn’t been tested this season, as three of their four games have been blowout wins. But in their loss in Arizona, the Cardinals ran for 222 yards and averaged 7.4 yards per carry.
Tonight, they’ll be facing the best running back in football in Christian McCaffrey, who is on an absolute heater. Given the mismatch of the 49ers’ offensive line vs. the Cowboys pass rush, I’m expecting a more conservative game plan from Kyle Shanahan, so I’ll be taking McCaffrey’s rushing yards over.
Pick: Christian McCaffrey over 78.5 rushing yards (-115 at DraftKings)
Soppe: The 49ers are pacing for a third straight season in which they allow fewer than 4.0 yards per carry, and if they shut down Tony Pollard, this could get ugly in a hurry.
With the 49ers consistently among the leaders in time of possession and Brock Purdy leading this offense to 30 points in every game, a lack of Dallas balance could put Dak Prescott in a spot where he is needed to produce big plays. Can he do that in this spot? Consider me skeptical. Here are his recent yards per completion marks:
- 2019-20: 12.5 yards per completion
- 2021-22: 10.9
- 2023: 9.4
San Francisco owns the seventh lowest blitz rate (eighth highest in hurry rate) through four weeks; a defensive game plan that suggests that chunk plays through the air by this underwhelming Cowboys offense is going to be hard to come by. Let’s cruise through the other teams set to struggle through Week 5.
- Steelers: Trubisky led this team to 6.2 yards/play vs BAL last season
- Panthers: High scoring environment, late points are very possible
- Texans: Pass-heavy scheme leads to scoring chances, can stop the clock
- Giants: High scoring environment, late points are very possible
- Saints: Expecting Derek Carr to show improved health
- Titans: The Colts are bottom five in time of possession; Derrick Henry is on track
- Jets: Face the Broncos …
This Cowboys/49ers game is the last game on Sunday, giving you a target score. Are you ready to roll the dice?
Pick: Dallas Cowboys to be the lowest scoring team on Sunday (+1700 at FanDuel)
Katz: It’s hard to get a read on the Cowboys passing game. They have yet to play a normal game. Three of their first four contests were noncompetitive blowouts with multiple defensive scores. The other one was a loss to the Cardinals, where the game wasn’t competitive in the other direction.
With that said, it sure looks like Brandin Cooks is a shell of his former self. He’s averaging just five targets a game and has yet to exceed 27 receiving yards. Yet, his line is set at 38.5.
Perhaps it’s this high because the expectation is this game will be competitive, and the Cowboys will have to throw to keep pace with the 49ers offense. But there’s a world where these two elite defenses dominate, keeping the game low-scoring. Either way, this line looks too high.
Cowboys vs. 49ers Pick: Brandin Cooks under 38.5 receiving yards (-110 at DraftKings)
Picks and Predictions for Every Game
Looking to get more advice for this week’s action? We’ve got picks and predictions for every matchup in Week 5. Use the table below to find the matchup you’re looking for.
