Eagles vs. Cardinals Picks, Predictions NFL Week 5: Hurts Looks to Best Murray

The Philadelphia Eagles are the NFC's most dominant team this season. They play the Arizona Cardinals on the road.

Eagles are the class of the NFC through the 2022 season's first quarter. Cardinals quarterback Kyler Murray will be consistent enough to beat former Sooner, Giants QB Jalen Hurts.

The Eagles are now favored by 5 points at DraftKings and 5 at FanDuel. 55% of the public money has been wagered on Philadelphia. 67% has also been bet on the Under.

Eagles vs. Cardinals is a betting game. The spread is 5 points. Over/under is 48.5 points, and DeVonta Smith is over 53. 5 receiving yards.

Eagles vs. Cardinals is a big game. The Eagles are favored by 5 points.

Eagles are 3-1 against the spread this season and Arizona is 2-2 ATS. The Eagles have won each of their first four games this year. Miles Sanders' resurgence has been a revelation for the Eagles offense. Arizona's run defense ranks in the top 10, but it hasn't faced a dual-threat quarterback like Hurts in recent weeks.

The Eagles average 28.8 points per game and the Cardinals average 22.0. The teams' combined scoring average is 50.5. Murray has been effective in late-game situations this season.

DeVonta Smith has had two dud games and two explosive games this season. Last week, he was held to 17 yards, but played the game in sloppy weather from Hurricane Ian's remnants. The Cardinals’ defense allows 255.8 passing yards per game, 23rd-most in 2022. FanDuel offers the prop at 55.5 yards. DraftKings offers a better value.

Eagles vs. Cardinals picks made 10/8/2022 at 3:32 p.m. ET.