English Premier League Southampton vs. Manchester City odds, picks: Predictions and best bets for Saturday's match from proven soccer insider

Last-place Southampton host Manchester City on Saturday in an English Premier match that is critical for both sides. Southampton (6-5-18) are desperate to avoid relegation and are within four points of five teams ahead of them in the table. Meanwhile, City (20-4-4) are second in the table, eight points behind league leader Arsenal. They are running out of time to close that gap in their attempt to defend their English Premier League title.        

Kickoff is set for 12:30 p.m. ET in Southampton, England. City are -410 favorites (risk $410 to win $100) in Caesars Sportsbook's latest Southampton vs. Manchester City odds, while the Saints are +1200 underdogs. A draw is priced at +450 and the over/under for total goals is 2.5. ()

Before you make any Manchester City vs. Southampton picks or any other English Premier League predictions, you MUST see what SportsLine soccer insider Martin Green has to say! 

After working in the sports betting industry for several years, Green became a professional sports writer and handicapper and has covered the game worldwide. Green is 70-76-2 (+3.05 units) on his SportsLine soccer picks in 2023, and he is 43-49 in his predictions on England's league and domestic cup competitions.

Green knows City thrashed Liverpool 4-1 last weekend, without Erling Haaland, the league's top scorer. Haaland returned to training this week and could be back, but City are loaded even without him. Julian Alvarez and Jack Grealish were among those who stepped up with goals last weekend. Kevin de Bruyne also was in the middle of it all, as usual. He has a league-high 13 assists for a Cityzens side that is plus-45 in goal differential (71-26) this season.

The expert also has considered that the hosts have been giving the top teams in the league fits the past few months. They beat Chelsea 1-0 at Stamford Bridge in February, then played to a scoreless draw with Manchester United at Old Trafford last month. They played to a 3-3 draw with Tottenham just before the break but lost to West Ham 1-0 last Sunday. James Ward-Prowse (seven goals) has been lethal on set pieces for the Saints.

Now, Green has taken an in-depth look at the Southampton vs. Manchester City match from every angle, and we can tell you he is leaning Over on the goal total. He has two other CONFIDENT best bets, including a strong handicap play, and his full breakdown of the match. You ABSOLUTELY need to see his picks and analysis before making any selections of your own.