Houston Astros at Los Angeles Angels odds, picks and prediction

Houston Astros (91-61) look for the sweep in their four-game series with the Los Angeles Angels (72-80). First pitch from Angel Stadium is scheduled for 9:38 p.m. ET. Astros' Lance McCullers Jr. (12-4, 3.11 ERA) makes his 27th start this season. Angels' Alex Cobb (8-3,3.59 ERA), who has a 1.23 WHIP, three BB/9 and 9.7 K/ 9, makes 17th starts.

Is 2-1 with a 2.10 ERA, 0.86 WHIP and 10.2 K/9 over 25 2/3 IP through four starts against the Angels in 2021. Owns a2.53 ERA and 11.8 K-9 through 64 IP across 11 starts on the road this year.

It was his second start since returning from the injured list. He pitched 5 scoreless innings on the road against the Chicago White Sox on Sept. 16.

Houston Astros are playing Los Angeles Angels.

Houston Astros have won the first three games of the series by a combined score of 29-10. Los Angeles is on a six-game losing streak. Houston is an elite-hitting team. The Astros are second in wRC+ and third in OPS in September. LA Angels are last in both categories in the month of September and against right-handed pitchers.

Cobb has had a resurgent season, but he is not beyond giving up a few runs in the right scenario. The Angels bullpen has been exceptional in September, whereas the Astros bullpen is having a difficult month. Houston is favored to win the game, while the Angels are going to pass on the total.