Iowa vs. Nevada prediction, odds, line: 2022 college football picks, Week 3 best bets from proven model

Iowa Hawkeyes are favored by 23 points against Nevada Wolf Pack at 7:30 p.m. on Saturday. The over/under is set at 39.5. Nevada is looking for a strong response after a loss to Incarnate Word. Iowa is 1-1 on the season after losing to Iowa State last Saturday and to South Dakota State in the opener. SportsLine's computer model simulates every FBS college football game 10,000 times and has returned a profit of almost $3,400 for $100 players on its top-rated collegefootball picks against the spread.

Iowa vs. Nevada is a college football game on Saturday. The line is Iowa -23.5. Iowa is favored by 1.25 points.

Iowa vs. Nevada is a college football game. The line is Iowa -23.5.

Iowa lost 10-7 to the Iowa State Cyclones on Saturday. Quarterback Spencer Petras had a slow start to his season. The defense has been a saving grace for Iowa, giving up just 13 points and 433 yards. Junior defensive lineman Logan Lee has had the most impactful play.

Nevada lost to Incarnate Word 55-41 on Saturday. Nevada's defense was the main issue. Iowa has done well to keep from giving up big plays. The Wolf Pack has allowed opponents to pick up more than ten yards on 37 plays so far this season.

The model simulates Iowa vs. Nevada 10,000 times and it's picking Nevada to win. The model is leaning Over on the point total and over 70% of simulations.