Louisville football vs. Virginia: Betting line, 3 things to know

Louisville football is 2-3 in the ACC and 0-2 in conference. The Cardinals lost to Boston College in Week 5. They have a bye next week, but have to travel to Virginia on Saturday. Virginia is also 2nd in ACC, with losses to Syracuse and Duke.

Brock Domann will start for Louisville against Virginia if Malik Cunningham can't play. Domanna played poorly against Boston College. He is not the same threat with his legs as Cunningham. Cardinals offensive lineman Caleb Chandler has confidence in both quarterbacks. They are both running quarterbacks at Louisville. The team's offensive line has the confidence of both. It's not possible to block for both players. If Cunningham is unable to play, Domanni will play in his place.

Louisville's offense needs to improve to beat Virginia. Running backs Jalen Mitchell, Tiyon Evans and Trevion Cooley are all questionable for Saturday's game. The Cardinals have a healthy group of receivers, but Dee Wiggins is out for the season. Offensive coordinator Lance Taylor is taking on more offensive duties. He wants his players to step up and improve the team's performance.

Virginia's new offensive system is not working well for the team's quarterback Brennan Armstrong. He's throwing only four touchdown passes this season. Louisville's defensive coordinator thinks it will take him some time to get used to the new system. Louisville and Virginia are playing each other on Saturday. The game is a betting line. It's a toss-up.

Louisville is a three-point favorite over Virginia on the road.

Louisville has a history of playing close games and not coming out on the winning side. Virginia has back-to-back conference losses but has talented quarterback and receivers. Cunningham's uncertain status plays a part in the game.