MLB Odds: Pirates-Cardinals prediction, odds, and pick

Pittsburgh Pirates and St. Louis Cardinals are playing in the 2022 MLB season opener. Pittsburgh finished the last season with a 61-101 record. St Louis won 90-72 and came within five games of the division-winning Milwaukee Brewers. Adam Wainwright will start for the Cardinals. JT Brubaker will get the start in Pittsburgh. The Cardinals won the 2011 World Series with Wainscott and Molina.

The Pirates are underdogs in the game against the Cardinals. Pittsburgh needs to get ahead early on and not let the Cards get comfortable. The Pirates were the lowest-scoring team in baseball during 2021. They need to make Cardinals ace Adam Wainwright work hard early in this game. The team that won the World Series in 2000 is the current favorite.

The Cardinals are looking to win the NL Central this year. They went 46-26 down the stretch last season and won a wild-card berth. Adam Wainwright has pitched 26 consecutive shutout innings against the Pirates. The Cardinals have a capable offense with Paul Goldschmidt and Nolan Arenado. The Pirates are the favorite to cover the spread.

The Cardinals are going to win this game by at least two runs. Wainwright will continue his dominance and put the Cardinals in the win column for the first time in 2022.