NFL Against the Spread Odds, Picks, Predictions for Week 16: Can Eagles Cover Without Hurts?

The Philadelphia Eagles and Dallas Cowboys meet on Christmas Eve in one of the most anticipated games of this season. There are three regular-season weeks left to pick the best NFL against-the-spread picks.

Tennessee Titans - 6 (-107 via PointsBet) vs. Houston Texans, Chicago Bears -8.5 (-106 via FanDuel Sportsbook) against Buffalo Bills, Philadelphia Eagles -6 (- 107 via DraftKings Sports betting) versus Dallas Cowboys.

Titans have lost four straight games and are 7-7 on the year. The Titans beat Cincinnati, Philadelphia, Jacksonville and the L.A. Chargers during their recent losing streak. Houston Texans lost by four to Dallas and by one to Kansas City. They were outgained 502-219 by the Chiefs.

Bears are favored by 8.5 points over the Bills. Buffalo is coming off a hard-fought 32-29 win over Miami that essentially clinched the AFC East. Chicago has lost seven straight games but is still playing with a lot of energy and enthusiasm. The line has already moved towards the Bears after Buffalo opened as 10-point favorites.

Jalen Hurts is expected to miss the game against the Cowboys because of a shoulder injury. The Eagles are 13-1 and their defense is ranked first against pass and second in total yards. Backup quarterback Gardner Minshew is more than capable of moving the offense through the air.

NFL Against the Spread Odds, Picks, Predictions for Week 16: Can Eagles Cover Without Hurts? NFL against-the-spread picks made 12/20/22 at 11:00 a.m. ET. Bonuses not applicable in Ontario.