NFL Against the Spread Picks for Week 5: Can the Bills Cover as Massive Favorites?

The Chicago Bears are the favorite against the spread in the Minnesota Vikings' first game back from London. The Buffalo Bills are massive favorites against a seven-point spread.

NFL Against the Spread picks for Week 5: Can the Bills Cover as Massive Favorites?

Bears have won three of their last four visits to Minnesota. Chicago's defense has held three opponents to 20 points or fewer. The Bears rank third in the NFL with 177 rushing yards per game. Minnesota's 23rd-ranked run defense is not the ideal place to play a division rival.

Patriots are off to a 1-3 start. They lost to the Dolphins, Ravens and Packers. The Patriots are playing Detroit at Ford Field this week. Their defense is ranked poorly, but their offense is good. Bills are the massive favorite. Bills cover as massive favorites at 3-0.

Bills beat the Ravens by three points. They are 14.5-point favorites against Pittsburgh Steelers. Kenny Pickett will start for the first time against a team that is ranked first against the pass and second in total yards and points allowed.   The team is also ranked second against pass yards, points and yards allowed, and third against quarterback.

NFL Against the Spread Picks for Week 5: Can the Bills Cover as Massive Favorites? NFL Week Five against the spread picks made 10/4/2022 at 8:41 a.m. ET.