NFL Week 5 Odds: Spreads, Moneylines, Totals, Betting Insights
The NFL's Week 5 slate features several games with big spreads. The week kicks off on Thursday with Denver Broncos and Indianapolis Colts. An AFC West showdown between the Kansas City Chiefs and Las Vegas Raiders will close out the week on Monday Night Football.
Colts lost 24-17 to Titans. Jonathan Taylor left the game with an ankle injury. Broncos lost to Las Vegas on Sunday. They outgained the Raiders by nearly a yard per play.
The New York Giants are 3-1 despite playing against the lowly Panthers, Titans and Bears. The Giants head to Green Bay with both Daniel Jones and Tyrod Taylor out. Green Packers were favored by 9.5 at home against New England, but the Patriots lost their starting quarterback to injury.
Pittsburgh Steelers are the underdogs against the Buffalo Bills in NFL Week 5. The rookie quarterback Kenny Pickett will start for the Steelers. Buffalo is the 3-1 and opened as huge home favorites.
LA Chargers are the favorite against the Cleveland Browns. The Browns lost as road favorites to the Falcons in Week 4. Myles Garrett is expected to miss a couple more weeks following his car accident.
The Vikings beat the Giants in the United Kingdom to get to 3-1 on the season. They are in first place in NFC North with a tiebreaker over Green Bay. The Bears were held to 12 points against the New York Giants. Chicago will try to pound the football on ground without lead RB David Montgomery.
Detroit Lions are 1-3 and their defense is very poor. They scored 45 points against Seattle in Week 4 but gave up 48. New England Patriots are 3-0 and have the best defense in the league.
Saints lost to Vikings, but they were without Jameis Winston, Michael Thomas and Alvin Kamara. Seattle piled up 48 points against Detroit. The Seahawks averaged 8.8 yards per play in Week 4, while the Saints are allowing only 5 per plays for the season.
Tua Tagovailoa was carted off the field with a concussion on Thursday Night Football. Teddy Bridgewater is the backup plan for Miami Dolphins. Zach Wilson struggled at times in his first start of the year, completing only 18 of 36 passes, but he threw for a score and caught one.
Atlanta Falcons beat the Browns on Sunday. Tampa Bay Buccaneers are 2-2 and play the Chiefs in Week 5. The spread could be as high as double-digits.
Tennessee Titans are back to .500 after two ugly losses. Derrick Henry ran for 100-plus yards for the second straight week. The Titans forced three turnovers and held Jonathan Taylor to 42 yards on 20 carries. Washington Commanders never sniffed a victory against Dallas. Carson Wentz was sacked 14 times in Weeks 2 and 3.
Houston Texans lost to the Chargers in Week 4. The Texans have a negative point margin of 20. Houston travels to Jacksonville to play the Jaguars. Jacksonville is 2-2 and blew a 14-point lead to Eagles in the fourth quarter.
The Carolina Panthers defense looked great again in Week 4, holding Kyler Murray and the Cardinals to 4.8 yards per play. Christian McCaffrey gained 27 yards on eight carries. The Panthers need to find chemistry on offense with the 49ers next on the schedule.
Dallas Cowboys are 3-0 without Dak Prescott under center. The Rams play against a hard-hitting Niners team on Monday Night Football and have a short week to prepare for the Cowboys.
Philadelphia Eagles are the last unbeaten team of 2022. They ran for 210 yards and four scores against Jacksonville on Sunday. The Eagles head to Arizona favored by more than a field goal.
Cincinnati Bengals have won two straight games after starting the season 0-2. Joe Burrow is coming off his best start of the year, averaging 9.3 yards per attempt in the win over Miami on Thursday. Baltimore's defense ranks among the worst at defensing the pass through four weeks.
The Raiders finally got a victory over Denver on Sunday. They will play the Chiefs at Arrowhead Stadium in Week 5.
