NFL Upset Picks, Predictions: Top Underdog Picks for Week 4

The top three NFL favorites lost outright in Week 3. Three undefeated teams took their first losses last week. The Los Angeles Chargers are the favorite against the Jacksonville Jaguars.

Lamar Jackson is the NFL's leading passer rating (119.0) and has 10 touchdown passes and 243 rushing yards. Jackson's team, the Ravens, is a heavy favorite against the Buffalo Bills. The Bills defense was without six starters against Miami Dolphins. Bills allowed 21 points despite possessing the ball for over 42 minutes and running 90 offensive plays.

The Chicago Bears are 2-1 and running the ball well. New York Giants are coming off a short week and playing their third consecutive home game. The Bears pressured San Francisco 49ers QB Trey Lance into 1-for-7 for minus-2 passing yards in the first game and they should do the same to Daniel Jones this week.

Arizona Cardinals lost their seventh consecutive home game for the first time since 1956-58. They have been an equally historic team on the road, having won seven straight games as road underdogs. Arizona lost to the Los Angeles Rams last week, but they are still a +100 favorite against Carolina Panthers.

NFL Upset Picks, Predictions and Top Underdog Picks for Week 4 are available at SportsbookReview.com.

NFL Upset Picks, Predictions: Top Underdog Picks for Week 4 are made 9/27/2022 at 2:14 p.m. ET.