Ohio State vs. Michigan State odds, spread, lines: Week 6 college football picks, predictions

Ohio State takes on Michigan State on Saturday. The Buckeyes are 25.5 points favorites. Michigan has lost three straight games. College Football Power Index computer predicts Ohio State will win. The computer projects Ohio state has a 78.2 percent chance to make the College football playoff. It also has the 24. 5 percent chances to win the national championship. MSU is ranked No. 32 on the index rankings this week. They are estimated to have won 5.3 games this season.