Ohio State vs. Missouri Cotton Bowl odds: Opening odds, point spread, total

We’re getting a Big Ten vs. SEC matchup in the Cotton Bowl when the Ohio State Buckeyes face the Missouri Tigers. The Buckeyes are likely still smarting from their loss to Michigan in “The Game” for the third year in a row, while the Tigers are on a high coming off their best season under head coach Eli Drinkwitz.

Here’s a look at the opening odds for this contest courtesy of DraftKings Sportsbook, along with our early prediction for how the game will play out.

Ohio State vs. Missouri opening odds for Cotton Bowl

Spread: Ohio State -6.5
Total: TBD

Early Prediction: Mizzou +6.5

We’ll have to see which players sit this one out, with Ohio State’s Marvin Harrison Jr. being the big name to watch. The Buckeyes could have some defensive players out too. The Tigers have consistently thrown out #STP this season, which stands for “Something to Prove”. They’ve done more than just prove they can be contenders, but Drinkwitz needs to cap off his spike season with a New Year’s Six win. I’m admittedly biased as a Missouri alum, but this Tigers team is more motivated. Plus, Mizzou tends to do big things in the Cotton Bowl.