Ohio State vs. Notre Dame odds, spread, line: 2022 college football picks

Ohio State and Notre Dame are playing in the first college football game of the season. The game is being played at Ohio Stadium in Columbus. Ohio State is the favorite, while the bookmakers name the Buckeyes as 17.5 point favorites. FPI named Ohio as the No. 2 team in its latest college rankings. Notre Notre has a 30.1 percent chance to make the College Football Playoff.