Oklahoma State vs. Central Michigan odds, prediction: 2022 Week 1 College football picks by model on 45-32 run

Oklahoma State Cowboys host Central Michigan Chippewas in the season opener on Thursday at 7 p.m. ET. Caesars Sportsbook lists Oklahoma State as a 21.5-point favorite. The over/under is 59. 5. SportsLine's advanced computer model simulates every FBS college football game 10,000 times and has returned a profit of almost $3,600 for $100 players on its top-rated collegeFootball picks against the spread.

Oklahoma State vs. Central Michigan is a college football game on September 21, 2022. The game is worth 21.5 points. Oklahoma State has won 12 straight games against non-Power 5 opponents.

Central Michigan vs. Oklahoma State money line is -2000, CMU +1050. The Chippewas won more games in 2022 than in any season since 2009. OSU has won 12 straight games against non-Power 5 opponents.

Central Michigan is on a five-game winning streak. The Chippewas are 20-13 since Jim McElwain took over. Central Michigan won nine games last season and beat Washington State in a bowl. Daniel Richardson returns as the starter at quarterback. Lew Nichols III is a running back who led FBS with 1,848 rushing yards last year.

Oklahoma State won 12 games last season. Mike Gundy's team is on a 16-year bowl streak. The Cowboys have won 28 of the last 29 games against non-Power 5 foes. Central Michigan is a good team. The model has a 45-32 record on college football picks.

SportsLine's model is leaning Under on the point total. Both teams are projected to score 51 points. One side of the spread hits in well over 60% of simulations.