Oregon vs. Arizona prediction, odds, line, spread: College football picks, Week 6 best bets from proven model

The 12th ranked Oregon Ducks travel to Arizona Stadium to take on the Arizona Wildcats in a Pac-12 matchup on Saturday night. Arizona is 3-2 overall and enters off a 43-20 home win against Colorado. Oregon is 4-1 and defeated Stanford 45-27 in Week 5. The teams met last year in Eugene, with Oregon winning comfortably 41-19.

SportsLine's computer model has set its sights on Arizona vs. Oregon and has made its picks and CFB predictions. Arizona is currently favored by 13.5 points.

Arizona vs. Oregon is a college football game. Arizona is favored by 13 points.

Arizona put on an offensive clinic against Colorado, generating 673 total yards. The Wildcats exploited the Buffaloes' poor defense through the air. Jacob Cowing has been one of the best receivers in the nation this season. Dorian Singer had 9 catches for 163 yards and a score, Tetairoa McMillan caught 5 passes for 90 yards, and he's now caught 40 passes this year for 566 yards with 7 scores.

Oregon's win over Stanford was Bo Nix's best performance since the opening day blowout against Georgia. NIX has now thrown for 12 touchdowns and rushed for five more on the season. The Ducks have scored 70, 41, 44, and 45 points in wins over Eastern Washington, BYU, Washington State, and Stanford since September 3rd.

The model has simulated Arizona vs. Oregon 10,000 times and the results are in. SportsLine's model is leaning Under on the point total and it's generated a point-spread pick that is hitting in almost 60% of simulations.