Penn State vs Northwestern betting line: Lions a huge home favorite again
![Penn State vs Northwestern betting line: Lions a huge home favorite again](/img/li/penn-state-vs-northwestern-betting-line-lions-a-huge-home-favorite-again-1.jpg)
Penn State is a 25.5-point favorite against Northwestern. The Lions are off to a 4-0 start for the 39th time in program history. Northwestern has lost three of its last four games. This will be the 20th meeting between the teams. Penn State holds a 14-5 advantage all-time. The Nittany Lions climbed from No. 14 to No 11 in the AP Top 25 poll after beating Central Michigan 33-14. They are the defending champions. Northwestern won in Dublin, Ireland.