San Francisco 49ers vs Seattle Seahawks TNF odds, picks & best props to bet

The San Francisco 49ers are the division-leading team and 3-point road favorites in the game against the Seattle Seahawks. The game is being streamed by Amazon as part of an exclusive agreement with the NFL. The start time is 8:15 pm ET.

The 49ers are 8-5 and the Seahawks are 3-3 at home. Seattle is 12-2 against the spread in the past 14 home games against San Francisco. The 49er's are getting 55% of handle and 73% bets in spread betting splits. A San Fran victory would clinch the NFC West title.

Brock Purdy started for the San Francisco 49ers last week and led them to a 35-7 win over the Tampa Bay Buccaneers. Seattle traded longtime starter Russell Wilson to Denver in the offseason. Journeyman Geno Smith has been the team's third-string quarterback recently.

Both teams have a number of players listed as questionable on their injury reports. The 49ers are without wide receiver Deebo Samuel and starting left defensive tackle Kevin Givens. Seattle played without rookie running back Kenneth Walker III last week.

The 49ers are the current No. 8 seed in the NFC. Seattle is currently the No 8. The Seahawks are 2-0 ATS this season as a home underdog. The 49er's recipe for success in Purdy's first start also happens to be the recent path to disaster for the Seahawks.

Seattle Seahawks are favored to beat the New York Giants. Newsweek earns an affiliate commission if you sign up through the links in this article.